The Serotonin Theory of Depression
نویسنده
چکیده
In its simplestfo rm, the serotonin deficiency theoryofdepression postulates that there is a net reduction in serotonin transmission in depressive illness. The pathophy siological change may result fr om two different mechanisms. Thejirst involves a decrease in serotonin (5-H T) availability which has the consequential tiffict ofcompensatory receptor up-regulation or supersensitiuity. The second mechanism impliesa primary defect in receptor activity and/ orsignal transduction. Theobjectioeqf this review is to analyze the serotonin system in depression as it relates to the above twopostulates.
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